Abstract Library

#2920 Mutation Spectrums Analysis of Colorectal Adenocarcinoma and Neuroendocrine Neoplasm Based on Same Genetic Background to Reveal Tumorigenesis

Introduction: The tumorigenesis of neuroendocrine neoplasm (NEN) are still ambiguous. The therapies of NENs in colon or rectum refer to adenocarcinomas (AC) when tumor metastasis, but the response was unsatisfactory which inspired us to explore the mutation difference.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Hu H

Authors: Cai W, Ge W, Wu D, Mao J, Hu H,

Keywords: Neuroendocrine neoplasm, Tumorigenesis, Mutation spectrums, Colorectal,

#2707 Investigating the Crosstalk between MEN1, p53 and Notch Reveals Biomarkers of Formation of Primary Pancreatic Neuroendocrine Tumors

Introduction: Pancreatic neuroendocrine tumors (PNETs) comprise a heterogeneous group of endocrine tumors. Previous studies showed that mutations of p53 are extremely rare; whereas genetic changes of MEN1 frequently occur and are correlated with poor prognosis in PNET. Still, their roles in tumorigenesis remain elusive.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Capodanno Y

Authors: Capodanno Y, Chen Y, Hiraoka N, Yokoyama A, Schrader J,

Keywords: MEN1, p53, Notch pathway, biomarkers, carcinogenesis, PNET,

#1161 Comparative Proteomic Analysis of Human Insulinoma and Its Clinical Implications in Pancreatic Neuroendocrine Tumors

Introduction: Insulinoma is the most common functional PNET. Its molecular tumorigenesis is largely unknown and proteomic study on insulinoma has not been reported

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Qiao X

Authors: Qiao X, Song Y, Bai C, Zhu L, Lu C,

Keywords: proteomics, pnet, UCH-L1, α-internexin, prognosis ,

#1115 Cancer Stem Cells in Small Intestine Neuroendocrine Cell Line P-STS: Isolation and Molecular Characterisation

Introduction: Cancer stem cells (CSCs) represent a small subpopulation of tumour cells responsible for invasive tumour growth. Even though the presence of CSCs in neuroendocrine tumours is documented, their role in neuroendocrine tumourigenesis and metastasis is not defined as yet.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Kleinegger F, Meier-Allard N, Fuchs R, Hölzl M, Krump C,

Keywords: Cancer stem cells, tumor growth, tumorigenesis & metastasis,

#992 Phase 1 and Phase 2 Clinical Trials Investigating Targets Against the Molecular Hallmarks of Gastroenteropancreatic Neuroendocrine Tumors

Introduction: Recently there have been many advances in the diagnosis and treatment of gastroenteropancreatic neuroendocrine tumors (GEP NETs), accompanied by significant improvements in our understanding of GEP NET biology. A number of well-established or novel molecular hallmarks are involved in GEP NET tumorigenesis and may help in identifying potential diagnostic or therapeutic targets.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Tamagno G

Authors: Tamagno G, Crespo G, Fierro Maya F, Fossmark R, Igaz P,

Keywords: neuroendocrine tumor, clinical trial, hallmark,